Innate Mucosal Sensing & Shaping of the Human-Microbiome

About Us

The Synnate program is defining the importance of host mucosal signalling pathways in resisting and restoring barrier integrity during homeostasis in equilibrium with the microbiome, and after disruption by infection and/or antibiotic treatment.

This will provide an exceptional knowledge gain to understand the molecular and biochemical consequences of mucosal disruption to the microbiome and the innate response, and allow us to go beyond models of association to intervention and restoration of mucosal health.

Our Research

Our research objectives are to define the innate responses to human microbiome compositions, their impact on pathology during mucosal injury and their effect on microbiome stability.

The unique skills of our diverse, multidisciplinary team in innate immunity, microbiome functional genomics, bacterial pathogenesis, cell-based discovery models, innovative bioengineering, data integration and systems biology offer an unprecedented opportunity to understand these interactions at a systems level.

Research Themes

We are working across four integrated research themes to apply a systems approach to understanding both host and microbiome responses at the mucosal surface.

Innate immune sensing of the human intestinal microbiome

Theme 1

Innate immune shaping of the intestinal microbiome

Theme 2

Tissue specificity in mucosal-microbiome interactions

Theme 3

Disruption of mucosal-microbiome interactions

Theme 4

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Our Team

Our diverse, multi-disciplinary team will create a new paradigms, platforms and resources to promote Australia’s research capacity in host-microbiome immunology.

Prof. Paul Hertzog

Prof. Paul Hertzog

Chief Investigator

Prof. Christine Wells

Prof. Christine Wells

Chief Investigator

Prof. Liz Hartland

Prof. Liz Hartland

Chief Investigator

Dr. Sam Forster

Dr. Sam Forster

Chief Investigator

Research Platforms

We are employing innovative technologies including iPSC-derived epithelium and immune cell models; molecular signaling pathway reporters and cutting edge bioengineering partnership on micro-fluidic based organ-on-a-chip technology.

Our Partners

Synnate is a partnership between the Hudson Institute of Medical Research and the University of Melbourne.

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